Ingvar M
Department of Clinical Neurophysiology, Karolinska Institute Hospital, Stockholm, Sweden.
Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1347-58. doi: 10.1098/rstb.1999.0483.
Functional neuroimaging has fundamentally changed our knowledge about the cerebral representation of pain. For the first time it has been possible to delineate the functional anatomy of different aspects of pain in the medial and lateral pain systems in the brain. The rapid developments in imaging methods over the past years have led to a consensus in the description of the central pain responses between different studies and also to a definition of a central pain matrix with specialized subfunctions in man. In the near future we will see studies where a systems perspective allows for a better understanding of the regulatory mechanisms in the higher-order frontal and parietal cortices. Also, pending the development of experimental paradigms, the functional anatomy of the emotional aspects of pain will become better known.
功能神经影像学从根本上改变了我们对大脑中疼痛的神经表征的认识。首次有可能描绘出大脑内侧和外侧疼痛系统中疼痛不同方面的功能解剖结构。过去几年成像方法的快速发展，使得不同研究对中枢疼痛反应的描述达成了共识，也促成了对人类具有专门子功能的中枢疼痛矩阵的定义。在不久的将来，我们将会看到一些研究，从系统的角度能够更好地理解高阶额叶和顶叶皮质中的调节机制。此外，随着实验范式的发展，疼痛情感方面的功能解剖结构也将为人所知。
