Choudhary D, Jansson I, Sarfarazi M, Schenkman J B
Department of Pharmacology and Molecular Ophthalmic Genetics Laboratory, University of Connecticut Health Center, Farmington, 06030, USA.
Drug Metab Rev. 2006;38(1-2):337-52. doi: 10.1080/03602530600570149.
Expression of 10 CYP orthologs (Families 1-3) in developing mouse conceptus is constitutive. These forms have specific temporal and spatial expression. Studies on CYP1B1 indicate its requirement for normal eye development, both in human and mouse. The distribution of the enzyme in the mouse eye is in three regions, which may reflect three different, perhaps equally important, functions in this organ. Its presence in the inner ciliary and lens epithelia appears to be necessary for normal development of the trabecular meshwork and its function in regulating intraocular pressure. Its expression in the retinal ganglion and inner nuclear layers may reflect a role in maintenance of the visual cycle. Its expression in the corneal epithelium may indicate a function in metabolism of environmental xenobiotics.
10种细胞色素P450直系同源物（1 - 3家族）在发育中的小鼠胚胎中的表达是组成性的。这些形式具有特定的时空表达。对细胞色素P450 1B1（CYP1B1）的研究表明，它对人类和小鼠的正常眼睛发育都是必需的。该酶在小鼠眼睛中的分布在三个区域，这可能反映了其在该器官中的三种不同但可能同样重要的功能。它在内侧睫状体和晶状体上皮中的存在似乎是小梁网正常发育及其调节眼内压功能所必需的。它在视网膜神经节和内核层中的表达可能反映了其在维持视觉循环中的作用。它在角膜上皮中的表达可能表明其在环境异生素代谢中的功能。
