Bubl Emanuel, Perlov Evgeniy, Tebartz Van Elst Ludger
Department of Psychiatry, Albert-Ludwigs-University, Freiburg, Germany.
World J Biol Psychiatry. 2006;7(2):123-5. doi: 10.1080/15622970500474770.
The treatment of the Gilles de la Tourette syndrome (GTS) is often challenging. One reason for this is the high neuropsychiatric cormorbidity in terms of ADHD or obsessive-compulsive symptoms. Dopaminergic modulation e.g. with antidopaminergic medication is an important part of the medical therapy aimed at motor and vocal tics. We report recent experiences with treatment with aripiprazole, a novel antipsychotic agent, which not only improved motor and vocal tics but also ameliorated some behavioural symptoms of the GTS cluster. Furthermore, we discuss possible pharmacological mechanisms for the observed effects.
抽动秽语综合征（GTS）的治疗往往具有挑战性。原因之一是在注意缺陷多动障碍（ADHD）或强迫症状方面存在高度的神经精神共病。多巴胺能调节，例如使用抗多巴胺能药物，是针对运动和发声抽动的药物治疗的重要组成部分。我们报告了使用新型抗精神病药物阿立哌唑治疗的近期经验，该药物不仅改善了运动和发声抽动，还减轻了GTS集群的一些行为症状。此外，我们讨论了观察到的效果可能的药理机制。
