Magill Paul, Ridgway Paul French, Conlon Kevin Christopher, Neary Paul
Department of General and Vascular Surgery, Trinity College Dublin, Adelaide Meath and National Childrens Hospital, Tallaght, Ireland.
JOP. 2006 May 9;7(3):311-4.
The incidence of drug-induced pancreatitis is rare. There have been no prior definite cases reported of ibuprofen-induced pancreatitis.
We present a case of a young man with acute pancreatitis probably secondary to an ibuprofen overdose. Immediately preceding the onset of the attack he took a 51 mg/kg dose of ibuprofen. He had other causes of acute pancreatitis excluded by clinical history, serum toxicology and abdominal imaging.
In the absence of re-challenge we believe it is probable that ibuprofen has a causative link with acute pancreatitis.
药物性胰腺炎的发病率很低。此前尚无布洛芬诱发胰腺炎的确切病例报道。
我们报告一例年轻男性急性胰腺炎病例，可能继发于布洛芬过量服用。在发病前他服用了51毫克/千克剂量的布洛芬。通过临床病史、血清毒理学检查和腹部影像学检查排除了其他导致急性胰腺炎的病因。
由于未进行再激发试验，我们认为布洛芬很可能与急性胰腺炎存在因果关系。
