皮肤中的紧密连接蛋白。
Tight junction proteins in the skin.
作者信息
Brandner J M, Kief S, Wladykowski E, Houdek P, Moll I
机构信息
Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Germany.
出版信息
Skin Pharmacol Physiol. 2006;19(2):71-7. doi: 10.1159/000091973. Epub 2006 May 9.
It has long been accepted that tight junctions (TJ) are crucial for the formation and maintenance of the paracellular barrier and for cell polarity in simple epithelia and endothelia. Moreover, it is long known that they play a role in barrier function of amphibian skin. However, only in recent years were TJ and TJ proteins identified in the epidermis of men and mice. Their involvement in the barrier function of mammalian skin has been shown. This review summarizes our current knowledge about TJ and TJ proteins in mammalian skin.
长期以来，人们一直认为紧密连接（TJ）对于简单上皮细胞和内皮细胞中细胞旁屏障的形成和维持以及细胞极性至关重要。此外，早就知道它们在两栖动物皮肤的屏障功能中发挥作用。然而，直到近年来才在人和小鼠的表皮中鉴定出紧密连接和紧密连接蛋白。它们在哺乳动物皮肤屏障功能中的作用已得到证实。这篇综述总结了我们目前关于哺乳动物皮肤中紧密连接和紧密连接蛋白的知识。
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