Tamai Yotaro, Imataki Osamu, Abe Yoshiaki, Hagiwara Shotaro, Ito Ichiro, Asakura Hirofumi, Harada Hideyuki, Kamata Minoru, Nishimura Tetsuo, Kawakami Kimihiro
Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center.
Gan To Kagaku Ryoho. 2006 May;33(5):687-90.
Nasal NK/T-cell lymphoma is EB virus-associated aggressive lymphoma, which is more prevalent in Asia. Previously, this lymphoma which was recognized as lethal midline granuloma, commonly presents with midline facial destructive lesions. In early stage I/II disease, radiation therapy exerts a powerful treatment outcome, however, toxic adverse events are indispensable and the tolerability of radiation therapy with chemotherapy has not been fully studied. It is imperative to offer an appropriate treatment for cure of this disease. We report consecutive 4 cases of nasal NK/T-cell lymphoma, which was treated with 56 Gy intensified local radiation therapy followed by systemic chemotherapy. Two cases complicated with grade 3 stomatitis during the treatment course and 3 cases were hospitalized due to the decrease of oral intake. The scheduled radiation chemotherapy was completed and resulted in complete response of disease in all cases. High intensified radiation therapy followed by chemotherapy may be effective for localized nasal NK/T-cell lymphoma.
鼻型NK/T细胞淋巴瘤是一种与EB病毒相关的侵袭性淋巴瘤，在亚洲更为常见。此前，这种淋巴瘤被认为是致死性中线肉芽肿，通常表现为中线面部破坏性病变。在早期I/II期疾病中，放射治疗具有显著的治疗效果，然而，毒性不良事件是不可避免的，且放射治疗联合化疗的耐受性尚未得到充分研究。为治愈这种疾病提供适当的治疗至关重要。我们报告了连续4例鼻型NK/T细胞淋巴瘤患者，采用56 Gy强化局部放射治疗，随后进行全身化疗。2例在治疗过程中并发3级口腔炎，3例因口服摄入量减少而住院。预定的放化疗完成后，所有病例均达到疾病完全缓解。高强化放疗后化疗可能对局限性鼻型NK/T细胞淋巴瘤有效。
