Rousseau F, Glenn O, Iordanova B, Rodriguez-Carranza C, Vigneron D, Barkovich J, Studholme C
University of California, San Francisco, USA.
Med Image Comput Comput Assist Interv. 2005;8(Pt 1):548-55. doi: 10.1007/11566465_68.
This paper describes a novel approach to forming high resolution MR images of the human fetal brain. It addresses the key problem of motion of the fetus by proposing a registration refined compounding of multiple sets of orthogonal fast 2D MRI slices, that are currently acquired for clinical studies, into a single high resolution MRI volume. A robust multi-resolution slice alignment is applied iteratively to the data to correct motion of the fetus that occurs between 2D acquisitions. This is combined with an intensity correction step and a super resolution reconstruction step, to form a single high isotropic resolution volume of the fetal brain. Experimental validation on synthetic image data with known motion types and underlying anatomy, together with retrospective application to sets of clinical acquisitions are included. Results indicate the method promises a unique route to acquiring high resolution MRI of the fetal brain in vivo allowing comparable quality to that of neonatal MRI. Such data is highly valuable in allowing a clinically applicable window into the process of normal and abnormal brain development.
本文描述了一种用于生成人类胎儿脑部高分辨率磁共振图像的新方法。它通过提出一种将多组正交快速二维磁共振成像切片（目前用于临床研究）进行配准细化合成，形成单个高分辨率磁共振成像体积的方法，解决了胎儿运动这一关键问题。一种稳健的多分辨率切片对齐方法被迭代应用于数据，以校正二维采集之间胎儿发生的运动。这与强度校正步骤和超分辨率重建步骤相结合，形成胎儿脑部的单个高各向同性分辨率体积。文中包括了对具有已知运动类型和基础解剖结构的合成图像数据的实验验证，以及对临床采集数据集的回顾性应用。结果表明，该方法有望为在体内获取胎儿脑部高分辨率磁共振成像提供一条独特途径，使其质量可与新生儿磁共振成像相媲美。这样的数据对于了解正常和异常脑发育过程的临床应用窗口具有极高价值。
