Tuganowski W
Department of Physiology, Silesian School of Medicine, Katowice, Poland.
J Physiol Pharmacol. 1991 Dec;42(4):397-406.
The effects of calmidazolium, carbachol and membrane permeable derivatives of cGMP (dipalmitoyl cGMP and 8-Bromo cGMP) on the longitudinal internal resistivity (Ri) were studied in the rabbit atrial trabeculae by means of electrophysiological recording techniques and histological planimetry. Calmidazolium as well as carbachol decreased Ri whereas cGMP-derivatives enhanced this resistivity. The effect of calmidazolium suggested that calmodulin reduced the cell coupling under control conditions. Carbachol decreased the Ca-inward current, and probably it prevented the calmodulin activation. The action of the nucleotides showed that cGMP did not mediate the cholinergic effect on the cell coupling. The possible interaction between calmodulin and cGMP was discussed.
采用电生理记录技术和组织学平面测量法，研究了氯米帕明、卡巴胆碱以及环鸟苷酸（cGMP）的膜通透性衍生物（二棕榈酰cGMP和8-溴cGMP）对兔心房小梁纵向内阻（Ri）的影响。氯米帕明和卡巴胆碱均可降低Ri，而cGMP衍生物可增强这种电阻。氯米帕明的作用表明，在对照条件下钙调蛋白降低了细胞耦联。卡巴胆碱降低了内向钙电流，可能阻止了钙调蛋白的激活。核苷酸的作用表明，cGMP并未介导胆碱能对细胞耦联的影响。讨论了钙调蛋白与cGMP之间可能的相互作用。
