[Binding of apolipoproteins to HDL receptors sites. Role in the efflux of cholesterol].

Cell surface binding sites recognizing artificial or native particles containing human apoAI, apoAII and/or apoAIV have been characterized in mouse Ob1771 adipose cells. These sites appear to be required for the promotion of cholesterol efflux from an intracellular pool. Two apoA-binding proteins of 92 and 80 kDa have been extensively purified from Ob1771 adipose cells. The critical role of both lipoprotein and receptor sites in cholesterol efflux is discussed.