Ailhaud G
Centre de Biochimie (CNRS UMR 134), Université de Nice-Sophia Antipolis.
Ann Endocrinol (Paris). 1991;52(6):467-8.
Cell surface binding sites recognizing artificial or native particles containing human apoAI, apoAII and/or apoAIV have been characterized in mouse Ob1771 adipose cells. These sites appear to be required for the promotion of cholesterol efflux from an intracellular pool. Two apoA-binding proteins of 92 and 80 kDa have been extensively purified from Ob1771 adipose cells. The critical role of both lipoprotein and receptor sites in cholesterol efflux is discussed.
已在小鼠Ob1771脂肪细胞中鉴定出识别含有人载脂蛋白AI、载脂蛋白AII和/或载脂蛋白AIV的人工或天然颗粒的细胞表面结合位点。这些位点似乎是促进细胞内胆固醇池流出所必需的。已从Ob1771脂肪细胞中大量纯化出两种分子量分别为92 kDa和80 kDa的载脂蛋白A结合蛋白。本文讨论了脂蛋白和受体位点在胆固醇流出中的关键作用。
