Kim Richard B
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Mol Pharm. 2006 Jan-Feb;3(1):26-32. doi: 10.1021/mp050084o.
Drug transporters are now increasingly recognized as important determinants of variable drug disposition and response. In addition, transporter associated problems appear to be occurring with greater frequency during the drug discovery and development process. What has not been clear is whether drug transporter related issues are a truly new problem, or whether such issues had existed all along, but were previously unrecognized or ignored. In this review, a brief overview of key drug transporters will be outlined. In addition, a commentary on specific issues of relevance to pharmaceutical sciences in terms of the role and relevance of drug transporters to the drug discovery and development process is provided.
药物转运体如今越来越被视为药物处置和反应变异性的重要决定因素。此外，在药物发现和开发过程中，与转运体相关的问题似乎出现得越来越频繁。尚不清楚的是，与药物转运体相关的问题究竟是一个全新的问题，还是这些问题一直存在，只是之前未被认识或忽视。在本综述中，将概述关键药物转运体的简要情况。此外，还将针对药物转运体在药物发现和开发过程中的作用及相关性，对与药学相关的具体问题进行评论。
