Corcoran Niall M, Costello Anthony J, Hovens Christopher M
Department of Urology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.
BJU Int. 2006 Jun;97(6):1149-53. doi: 10.1111/j.1464-410X.2006.06198.x.
Authors from Australia describe how interfering with cell survival is increasingly being chosen as a method of developing a treatment strategy for hormone-resistant prostate cancer. The authors show how several developmental drug candidates have preclinical and clinical activity against cell survival proteins, and that these might be worth considering as possible clinical entities in this condition. The commonly stated argument that laparoscopy has advanced the cause of donor nephrectomy in renal transplantation is examined by authors from the UK. They present a review of the published reports and show that the evidence base is poor for drawing a conclusion as to whether laparoscopic or open nephrectomy is best.
来自澳大利亚的作者描述了干扰细胞存活如何越来越多地被选作一种开发激素抵抗性前列腺癌治疗策略的方法。作者展示了几种处于研发阶段的候选药物如何对细胞存活蛋白具有临床前和临床活性，并且这些药物在这种病症中可能值得作为潜在的临床实体来考虑。来自英国的作者审视了关于腹腔镜检查推动了肾移植中供体肾切除术发展这一普遍观点。他们对已发表的报告进行了综述，并表明关于腹腔镜肾切除术还是开放性肾切除术更佳这一问题，目前的证据基础薄弱，难以得出结论。
