某些4'-硫代-2'-脱氧核苷类似物的合成及其抗病毒活性
The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues.
作者信息
Dyson M R, Coe P L, Walker R T
机构信息
School of Chemistry, University of Birmingham, UK.
出版信息
Nucleic Acids Symp Ser. 1991(24):1-4.
PMID:1668682
Abstract
A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis.
摘要
本文描述了苄基3,5-二-O-苄基-2-脱氧-1,4-二硫代-D-赤藓糖戊呋喃糖苷的一种实用的7步合成方法，该产物已用于某些4'-硫代-2'-脱氧核苷的合成。这些新型核苷类似物具有潜在的有用生物活性，并且对磷酸解具有抗性。
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