Chen Wei, Srinivasan Sathanur R, Li Shengxu, Berenson Gerald S
Tulane Center for Cardiovascular Health and the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
J Clin Hypertens (Greenwich). 2006 May;8(5):323-9. doi: 10.1111/j.1524-6175.2005.04875.x.
Differential impact of non-high-density lipoprotein cholesterol (total cholesterol minus high-density lipoprotein cholesterol) and blood pressure on arterial wall thickness and stiffness was examined in 900 black and white adults aged 24-43 years. Blacks compared with whites had greater values of pulse wave velocity (5.4 m/sec vs. 5.2 m/sec; p<0.01) and carotid artery intima-media thickness (0.83 mm vs. 0.80 mm; p<0.01). Non-high-density lipoprotein cholesterol was significantly associated with carotid intima-media thickness (standardized regression coefficient [b]=0.21; p<0.01), but not with pulse wave velocity (b=0.03; p=0.37), after adjusting for race, sex, age, body mass index, insulin, glucose, and smoking. Systolic blood pressure was associated significantly stronger with pulse wave velocity (b=0.36; p<0.01) than with carotid intima-media thickness (b=0.15; p<0.01). No race difference in these relationships was found. The results of this study indicate that atherogenic lipoproteins and blood pressure may play different roles in the development of arterial wall stiffness and atherosclerosis.
在900名年龄在24至43岁的黑人和白人成年人中，研究了非高密度脂蛋白胆固醇（总胆固醇减去高密度脂蛋白胆固醇）和血压对动脉壁厚度和硬度的不同影响。与白人相比，黑人的脉搏波速度更高（5.4米/秒对5.2米/秒；p<0.01），颈动脉内膜中层厚度更大（0.83毫米对0.80毫米；p<0.01）。在调整种族、性别、年龄、体重指数、胰岛素、血糖和吸烟因素后，非高密度脂蛋白胆固醇与颈动脉内膜中层厚度显著相关（标准化回归系数[b]=0.21；p<0.01），但与脉搏波速度无关（b=0.03；p=0.37）。收缩压与脉搏波速度的相关性（b=0.36；p<0.01）显著强于与颈动脉内膜中层厚度的相关性（b=0.15；p<0.01）。在这些关系中未发现种族差异。本研究结果表明，致动脉粥样硬化脂蛋白和血压在动脉壁僵硬和动脉粥样硬化的发展中可能起不同作用。
