髌骨铅含量与血铅及胫骨铅含量的比较及其与神经行为测试分数的关联。
Comparison of patella lead with blood lead and tibia lead and their associations with neurobehavioral test scores.
作者信息
Dorsey Carrie D, Lee Byung-Kook, Bolla Karen I, Weaver Virginia M, Lee Sung-Soo, Lee Gap-Soo, Todd Andrew C, Shi Weiping, Schwartz Brian S
机构信息
Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
出版信息
J Occup Environ Med. 2006 May;48(5):489-96. doi: 10.1097/01.jom.0000199678.86629.3b.
OBJECTIVE
Lead exposure in adults is associated with worse cognitive function in cross-sectional and longitudinal studies. Previous studies have mainly examined relations with blood lead or cortical bone lead; few have examined trabecular bone lead.
METHODS
We performed a cross-sectional analysis of the relations of patella lead and other lead biomarkers with measures of neurobehavioral and peripheral nervous system function in 652 lead workers.
RESULTS
Patella lead was found to be associated with worse performance on seven of 19 tests of manual dexterity, sensory vibration threshold, and depressive symptoms. The associations of patella lead with cognitive function were essentially similar to those with blood lead or tibia lead but of somewhat lower magnitude.
CONCLUSIONS
In this study, measurement of patella lead did not aid causal inference regarding cognitive effects when compared with blood lead and tibia lead.
目的
在横断面研究和纵向研究中，成人铅暴露与较差的认知功能相关。既往研究主要探讨了与血铅或皮质骨铅的关系；很少有研究考察小梁骨铅。
方法
我们对652名铅作业工人的髌骨铅及其他铅生物标志物与神经行为和周围神经系统功能指标的关系进行了横断面分析。
结果
在19项关于手部灵巧性、感觉振动阈值和抑郁症状的测试中，有7项发现髌骨铅与较差的表现相关。髌骨铅与认知功能的关联与血铅或胫骨铅的关联基本相似，但程度略低。
结论
在本研究中，与血铅和胫骨铅相比，测量髌骨铅无助于对认知效应进行因果推断。
Zotero 插件