Freedman A M, Cassidy M M, Weglicki W B
Department of Medicine, George Washington University Medical Center, Washington, D.C.
Magnes Trace Elem. 1991;10(5-6):348-54.
We have previously established a link between magnesium-deficiency-induced cardiomyopathy and free radical injury. In the present study, golden Syrian male hamsters were placed on either magnesium-deficient or magnesium-supplemented diets. Animals from each group received either d,l-propranolol or d-propranolol (the non-beta-blocking form). After 14 days, the animals were sacrificed and their hearts isolated for morphological and morphometric analyses. Hematoxylin/eosin-stained sections were examined by a computer image analysis system for a morphometric determination of the severity of myocardial injury. Propranolol reduced both the density of lesions, from 0.32 to 0.06 lesions/mm2 (p < 0.01), and the area fraction of lesions, from 9.8 x 10(-4) to 2.5 x 10(-4) lesion area/mm2 (p < 0.01). In addition, d-propranolol was virtually equipotent to d,l-propranolol, indicating that part of the protective effect of propranolol, in this model, was attributable to its antioxidant properties.
我们之前已确立了镁缺乏诱导的心肌病与自由基损伤之间的联系。在本研究中，将金黄叙利亚雄性仓鼠分别置于缺镁饮食或补充镁的饮食中。每组动物分别给予d，l-普萘洛尔或d-普萘洛尔（非β受体阻断形式）。14天后，处死动物并取出心脏进行形态学和形态计量学分析。苏木精/伊红染色切片由计算机图像分析系统检查，以对心肌损伤的严重程度进行形态计量学测定。普萘洛尔使损伤密度从0.32个损伤/mm²降至0.06个损伤/mm²（p<0.01），并使损伤面积分数从9.8×10⁻⁴损伤面积/mm²降至2.5×10⁻⁴损伤面积/mm²（p<0.01）。此外，d-普萘洛尔与d，l-普萘洛尔几乎等效，表明在该模型中普萘洛尔的部分保护作用归因于其抗氧化特性。
