Leon A, Lepousé C, Floch T, Graftieaux J-P
Département d'Anesthésie-Réanimation, Hôpital Robert-Debré, 51092 Reims cedex, France.
Ann Fr Anesth Reanim. 2006 Aug;25(8):863-7. doi: 10.1016/j.annfar.2006.03.011. Epub 2006 May 11.
Sepsis-associated encephalopathy is a global cerebral dysfunction induced by the systemic response to inflammation and infection, without a liver or renal injury. Alteration of consciousness, from confusion to coma, is the main clinical symptom. This encephalopathy is associated with an increase in mortality due to sepsis. Its physiopathology is unknown. There is frequently an increased permeability of the blood-brain barrier, which might explain a role of endotoxins on cerebral metabolism. Changes in neurotransmitter release or concentrations (norepinephrine, serotonin, dopamine, GABA) have been reported. There is not any specific treatment of septic encephalopathy. In most cases, this syndrome is rapidly reversible after the treatment of sepsis.
脓毒症相关性脑病是一种由全身炎症和感染反应引起的全脑功能障碍，不存在肝或肾损伤。意识改变，从意识模糊到昏迷，是主要临床症状。这种脑病与脓毒症导致的死亡率增加有关。其病理生理学尚不清楚。血脑屏障通透性常常增加，这可能解释了内毒素对脑代谢的作用。有报道称神经递质释放或浓度（去甲肾上腺素、血清素、多巴胺、γ-氨基丁酸）发生了变化。脓毒症性脑病没有任何特异性治疗方法。在大多数情况下，该综合征在脓毒症治疗后可迅速逆转。
