Montag Anthony G, Tretiakova Maria, Richardson Mary
Laboratory of Surgical Pathology, University of Chicago, Chicago, IL 60637, USA.
Am J Clin Pathol. 2006 Jun;125(6):832-7. doi: 10.1309/W5CM-3A3N-H7P4-F5P2.
Nasopharyngeal angiofibroma is an uncommon tumor arising in adolescent males, suggesting that the tumor may be hormonally responsive. Previous studies have found androgen receptor (AR) expression but variable expression of estrogen receptor (ER). The recently described ss receptor for estrogen has not been analyzed in angiofibroma. We analyzed 13 cases of nasal angiofibroma by immunohistochemical analysis for the presence of ARs, progesterone receptors (PR), and ER-a and ER-ss. All 13 cases were positive for ER-ss, in stromal pericytic and endothelial cells, and 12 of 13 stained strongly. Five cases were positive for AR in stromal cells, most staining weakly, and with no staining in endothelial or pericytic cells. None of the cases displayed staining for ER-a or PR. The findings confirm that nasopharyngeal angiofibromas express ER and suggest that new modulators of ER-ss activity may provide an alternative therapy for these lesions.
鼻咽血管纤维瘤是一种发生于青春期男性的罕见肿瘤，提示该肿瘤可能对激素有反应。既往研究发现有雄激素受体（AR）表达，但雌激素受体（ER）表达各异。最近描述的雌激素β受体尚未在血管纤维瘤中进行分析。我们通过免疫组化分析对13例鼻血管纤维瘤病例检测了AR、孕激素受体（PR）、ER-α和ER-β的表达情况。所有13例病例的间质周细胞和内皮细胞中ER-β均呈阳性，13例中有12例强染色。5例病例的间质细胞中AR呈阳性，多数为弱染色，内皮细胞和周细胞无染色。所有病例均未显示ER-α或PR染色。这些发现证实鼻咽血管纤维瘤表达ER，并提示ER-β活性的新调节剂可能为这些病变提供一种替代治疗方法。
