Ladny J R, Grycz A, Trochimowicz L, Puchalski Z
Kliniki Chirurgii Ogólnej AM, Białymsto.
Pol Tyg Lek. 1991;46(22-23):430-2.
An effect of hydrocortisone and dopamine on beta-glucuronidase activity in the lung tissue in experimental septic shock was analysed. The study involved 30 mongrel dogs. Septic shock was induced with i.v. E. coli endotoxin. Total and free activity of beta-glucuronidase was determined with Talalay et al. technique in pulmonary parenchyma homogenate, mitochondrial-lysosomal fraction and supernatant. It was found, that hydrocortisone and dopamine given together increase the stability of the pulmonary lysosomes indicating a value of such management of the septic shock in man.
分析了氢化可的松和多巴胺对实验性脓毒症休克时肺组织中β-葡萄糖醛酸酶活性的影响。该研究涉及30只杂种犬。通过静脉注射大肠杆菌内毒素诱导脓毒症休克。采用Talalay等人的技术测定肺实质匀浆、线粒体-溶酶体组分和上清液中β-葡萄糖醛酸酶的总活性和游离活性。结果发现，氢化可的松和多巴胺联合使用可提高肺溶酶体的稳定性，这表明这种治疗脓毒症休克的方法对人类具有价值。
