Magnusson Linda L, Bodin Lennart, Wennborg Helena
Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Huddinge, Sweden.
Am J Ind Med. 2006 Jun;49(6):468-73. doi: 10.1002/ajim.20317.
Laboratory work may constitute a possible health hazard for workers as well as for their offspring, and involves a wide range of exposures, such as organic solvents, carcinogenic agents, ionizing radiation, and/or microbiological agents. Adverse pregnancy outcomes in the offspring of male employees in biomedical research laboratories are examined.
Offspring to males employed 1970-1989 at four Swedish universities were identified via the Medical Birth Register (MBR), along with other pregnancy parameters. Offspring of fathers with laboratory work (n = 2,281) is considered exposed, and of non-laboratory employees unexposed (n = 1,909). Exposure data were obtained by questionnaires to research group leaders. Logistic regression analysis estimated odds ratios (ORs) and 95% confidence intervals (CIs).
Paternal laboratory work in general showed no statistically significant increased ORs concerning birth weight and/or gestational age, but work specifically with radioactive isotopes gave OR 1.8 (CI 1.0-3.2) for high birth weight and a relative risk of 1.2 (CI 1.0-1.4) for sex ratio (male/female).
There was no clear association between periconceptional paternal laboratory work and adverse reproductive outcomes, but use of radioactive isotopes showed increased OR for high birth weight in offspring.
实验室工作可能对工作人员及其后代构成潜在的健康危害，涉及多种暴露因素，如有机溶剂、致癌物质、电离辐射和/或微生物制剂。本文对生物医学研究实验室男性员工后代的不良妊娠结局进行了研究。
通过瑞典医疗出生登记册（MBR）确定了1970年至1989年在四所瑞典大学工作的男性的后代以及其他妊娠参数。父亲从事实验室工作的后代（n = 2281）被视为暴露组，父亲为非实验室员工的后代（n = 1909）被视为非暴露组。通过向研究小组负责人发放问卷获取暴露数据。采用逻辑回归分析估计比值比（OR）和95%置信区间（CI）。
总体而言，父亲的实验室工作在出生体重和/或孕周方面未显示出具有统计学意义的OR增加，但专门从事放射性同位素工作的OR为1.8（CI 1.0 - 3.2），表明出生体重高，性别比（男/女）的相对风险为1.2（CI 1.0 - 1.4）。
受孕前父亲的实验室工作与不良生殖结局之间没有明确关联，但使用放射性同位素显示后代出生体重高的OR增加。
