Pillarisetti Jayasree, Duthuluru Sowjanya, Sayana Hari, Goucher Haley Goucher, Patel Akshar, Biria Mazda, Vacek James, Berenbom Loren, Bommana Sudharani, Nath Jayan, Wiley Mark, Nangia Ajay, Di Biase Luigi, Natale Andrea, Reddy Madhuri, Dawn Buddhadeb, Lakkireddy Dhanunjaya
Cardiovascular Research Institute, Center for Advanced Heart Care, Division of Cardiovascular Diseases, Dept. of Obstetrics and Gynecology and the Division of Urology and Andrology, University of Kansas Medical Center and Hospital, Kansas City, KS, University of Missouri Kansas City, Kansas City, MO and Texas Cardiac Arrhythmia Institute at St. David Medical Center, University of Texas, Austin, Texas.
J Atr Fibrillation. 2013 Apr 6;5(6):801. doi: 10.4022/jafib.801. eCollection 2013 Apr-May.
Fluoroscopic radiation has been implicated in reducing the sex ratio (M:F) by potentially damaging the Y chromosome. We examined the effects of exposure to fluoroscopic radiation on gender of offspring of cardiologists across the world. An internet based survey was e-mailed worldwide to 8000 physicians who practice invasive electrophysiology and/or interventional cardiology. Survey questions included age, race, sub-specialty, hours of exposure to radiation, number of children, gender of off-spring, miscarriages and mutations and exposure to radiation prior to conception of each child. Logistic regression analyses were performed on years of exposure and gender of offspring born post radiation exposure. Responses of 377 cardiologists (84% male and 16% female) were reviewed. With a total of 398 males and 402 females born to 377 cardiologists, although reduced, the overall sex ratio (0.99) was not significantly different from that observed in the general population (1.05). Univariate logistic regression analysis identified higher male births with increasing hours of radiation exposure (OR 1.034, CI 1.003-1.067 p=0.03) and increasing paternal age (OR 1.05, CI 1.01-1.08, p=0.002). Subgroup analysis of children of male cardiologists revealed higher incidence of male births with increasing age and radiation exposure and multivariate analysis only identified paternal age as predictor of higher incidence of male births (OR 1.05, CI 1.01-1.089, p=0.0027). Exposure to ionizing radiation leads to a decrease in the sex ratio (M/F) in younger male cardiologists, while this effect is reversed with greater number of male births in older male cardiologists.
透视辐射可能会损害Y染色体，进而导致性别比例（男：女）降低。我们研究了全球心脏病专家接触透视辐射对其后代性别的影响。通过互联网向全球8000名从事侵入性电生理学和/或介入心脏病学的医生发送了调查问卷。调查问题包括年龄、种族、亚专业、辐射暴露时间、子女数量、后代性别、流产和突变情况以及每个孩子受孕前的辐射暴露情况。对辐射暴露后的年份和后代性别进行了逻辑回归分析。对377名心脏病专家（84%为男性，16%为女性）的回复进行了审查。377名心脏病专家共生育了398名男性和402名女性，尽管性别比例有所降低（0.99），但与一般人群中观察到的比例（1.05）并无显著差异。单因素逻辑回归分析发现，随着辐射暴露时间的增加，男性出生比例升高（比值比1.034，置信区间1.003 - 1.067，p = 0.03），且父亲年龄增加也有同样情况（比值比1.05，置信区间1.01 - 1.08，p = 0.002）。对男性心脏病专家子女的亚组分析显示，随着年龄和辐射暴露的增加，男性出生的发生率更高，多因素分析仅确定父亲年龄是男性出生发生率较高的预测因素（比值比1.05，置信区间1.01 - 1.089，p = 0.0027）。电离辐射暴露会导致年轻男性心脏病专家的性别比例（男/女）下降，而在年长男性心脏病专家中，随着男性出生数量增多，这种影响则相反。
