Mach T, Basista M, Bogdał J, Kostka-Trabka E
Kliniki Gastroenterologii Instytutu Medycyny Wewnetrznej.
Pol Tyg Lek. 1991;46(45-47):892-5.
An effect of the locally produced antacids on PGE2 in the gastric mucosa has been studied both clinically and experimentally. It was found, that such preparations as Alugastrin, Gastrin, and Vikalin administered chronically to the rats accelerate healing rate of peptic ulcer, decreasing in the same time the PGE2 level in the gastric mucosa. Alugastrin in a single oral dose significantly increased pH of the stomach and did not affect endogenous PGE2 level. Some locally produced antacids exert an effect on endogenous PGE2 production in the gastric mucosa, which could be important for their efficacy.
已经从临床和实验两方面研究了本地生产的抗酸剂对胃粘膜中前列腺素E2（PGE2）的影响。研究发现，长期给大鼠服用诸如铝加司琼、胃泌素和维卡林等制剂，可加速消化性溃疡的愈合速度，同时降低胃粘膜中PGE2的水平。单次口服铝加司琼可显著提高胃内pH值，且不影响内源性PGE2水平。一些本地生产的抗酸剂对胃粘膜中内源性PGE2的产生有影响，这可能对其疗效具有重要意义。
