Synergistic effects of fad and acth on the 32-p turnover in the adrenal of rats treated with a one shot administration of dexamethasone phosphate.

The effects of Flavin Adenine Dinucleotide (FAD) and of vitamin A for two days to 25 days old rats has been studied on liver of rats treated with a one shot administration of dexamethasone phosphate were investigated. Efforts were made to determine whether or not ACTH participates in the action of FAD which affects adrenal atrophy induced by steroid hormone administration. The large decrease in adrenals 32-P turnover in rat treated with a one shot administration of dexamethasone phosphate was reduced by intraperitoneal administration of FAD or ACTH alone. This tendency of reduced loss was further promoted by an administration of ACTH simultaneously with the FAD. These results suggest the presence of a new physiological role for FAD i.e. FAD is able to potentiate the action of ACTH. The role was discussed of a possible synergism between FAD and ACTH with regard to their action on the induction of adrenal atrophy by steroid administration.