Stiller Ibolya, Pusztai Rozália, Sombor Erzsébet, Orosz L, Pál A, Taródi B
Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.
Acta Microbiol Immunol Hung. 2006 Mar;53(1):25-34. doi: 10.1556/AMicr.53.2006.1.2.
The prevalence, the level and the avidity of human herpesvirus-6 (HHV-6) specific IgG were examined in pregnant women and age-matched female blood donors. The study group consisted of 180 women (age 14-45); 60 women with normal pregnancy, 60 pregnant women with fetuses suspected of having any viral infection and 60 healthy blood donors with no history of pregnancy. Plasma or serum samples were tested for HHV-6 IgG antibodies by an immunofluorescence assay. Ninety-eight percent of blood donors and 97% of 120 pregnant women had IgG antibodies to HHV-6. The rate of seropositivity in women with normal pregnancies and women with fetuses suspected to have viral infection was the same. Pregnant women (n = 120) had significantly lower antibody titer than blood donors. No significant differences were found in the same respect between the two groups of pregnant women. Low avidity of IgG antibodies to HHV-6 was detected in 5% of pregnant women.
在孕妇和年龄匹配的女性献血者中检测了人类疱疹病毒6型（HHV-6）特异性IgG的流行率、水平和亲和力。研究组由180名女性（年龄14 - 45岁）组成；60名正常妊娠女性、60名胎儿疑似有任何病毒感染的孕妇和60名无妊娠史的健康献血者。通过免疫荧光测定法检测血浆或血清样本中的HHV-6 IgG抗体。98%的献血者和97%的120名孕妇有HHV-6的IgG抗体。正常妊娠女性和胎儿疑似有病毒感染的女性的血清阳性率相同。孕妇（n = 120）的抗体滴度显著低于献血者。两组孕妇在这方面未发现显著差异。5%的孕妇检测到HHV-6 IgG抗体的低亲和力。
