van den Elzen B D J, Boeckxstaens G E E
Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
Aliment Pharmacol Ther. 2006 Jun 1;23(11):1499-510. doi: 10.1111/j.1365-2036.2006.02930.x.
Several important pathophysiological mechanisms have been identified in functional dyspepsia, however a complete understanding of these mechanisms and beneficial therapeutic strategies are still lacking. Based on the currently available literature we aimed at providing a critical view on one of these pathophysiological mechanisms, impaired accommodation. Although impaired gastric accommodation is identified as a major pathophysiological mechanism, the clinical evidence supporting its role as an important therapeutic target is currently still lacking. Treatment with fundic relaxant drugs has shown conflicting results and has been rather disappointing in general. These negative findings could be explained by the fact that impaired fundic accommodation is part of a more complex disorder involving other regions of the proximal gut or by the increasing insight that central mechanisms may play an important role. Future studies of impaired accommodation should take these considerations into account.
在功能性消化不良中已确定了几种重要的病理生理机制，然而，对这些机制及有益治疗策略仍缺乏全面的了解。基于现有文献，我们旨在对其中一种病理生理机制——容受性舒张功能受损进行批判性审视。尽管胃容受性舒张功能受损被认为是主要的病理生理机制，但目前仍缺乏支持其作为重要治疗靶点的临床证据。使用胃底松弛药物治疗的结果相互矛盾，总体上令人失望。这些负面结果可能是由于胃底容受性舒张功能受损是涉及近端肠道其他区域的更复杂疾病的一部分，或者是由于越来越多的认识表明中枢机制可能起重要作用。未来关于容受性舒张功能受损的研究应考虑这些因素。
