应对数量基因组学这头“大象”：基因必要性与进化速率之间的相关性
Coping with the quantitative genomics 'elephant': the correlation between the gene dispensability and evolution rate.
作者信息
Wolf Yuri I
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
出版信息
Trends Genet. 2006 Jul;22(7):354-7. doi: 10.1016/j.tig.2006.04.009. Epub 2006 May 11.
Early studies suggested that proteins with a greater contribution to the fitness of an organism evolve more slowly than less 'important' proteins. Recent articles by two research groups highlight the long-standing controversy about the genome-wide relationships between the measures of evolution rate, protein abundance and the fitness effect of gene disruption. These studies highlight the need for truly multidimensional approaches to the issues of quantitative genomics.
早期研究表明，对生物体适应性贡献更大的蛋白质，其进化速度比不那么“重要”的蛋白质要慢。两个研究小组近期发表的文章突出了一个长期存在的争议，即进化速率、蛋白质丰度和基因破坏的适应性效应之间在全基因组范围内的关系。这些研究凸显了采用真正的多维方法来解决定量基因组学问题的必要性。
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