Berger R, Bernard O A
EMI 0210 Inserm, Tour Pasteur, Hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75743 Paris cedex 15, France.
Pathol Biol (Paris). 2007 Feb;55(1):56-8. doi: 10.1016/j.patbio.2006.04.004. Epub 2006 May 11.
A translocation t(1;22)(p13;q13) was detected in a child with T-cell acute lymphoblastic leukemia (T-ALL). FISH studies showed that the breakpoint was located in the 5' part of the interleukin-2 receptor beta chain (IL2RB) locus, but could only be located distal to 1p13.3 on the partner chromosome. This is the first case of the IL2RB locus rearrangement in T-ALL. The localization of the breakpoint suggests that the chromosomal translocation results in deregulation of IL2RB expression.
在一名患有T细胞急性淋巴细胞白血病（T-ALL）的儿童中检测到一种t(1;22)(p13;q13)易位。荧光原位杂交（FISH）研究表明，断点位于白细胞介素-2受体β链（IL2RB）基因座的5'部分，但在配对染色体上仅能定位到1p13.3远端。这是T-ALL中IL2RB基因座重排的首例病例。断点的定位表明染色体易位导致IL2RB表达失调。
