Kawata Kimiko, Li Yan, Liu Hao, Zhang Xiao Qin, Ushijima Hiroshi
Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 1130033, Japan.
Int J Hyg Environ Health. 2006 Jul;209(4):377-83. doi: 10.1016/j.ijheh.2006.03.003. Epub 2006 May 11.
The objectives of this study are to examine the prevalence of increased blood lead concentrations in mothers and their umbilical cords, and to identify risk factors for prenatal lead exposure in Kunming city, Yunnan province, China. The study was conducted at two obstetrics departments, and 100 peripartum women were enrolled. The mean blood lead concentrations of the mothers and the umbilical cords were 67.3microg/l and 53.1microg/l, respectively. In multiple linear regression analysis, maternal occupational exposure, maternal consumption of homemade dehydrated vegetables and maternal habitation period in Kunming city were significantly associated with an increase of umbilical cord blood lead concentration. In addition, logistic regression analysis was used to assess the association of umbilical cord blood lead concentrations that possibly have adverse effects on brain development of newborns with each potential risk factor. Maternal frequent use of tableware with color patterns inside was significantly associated with higher cord blood lead concentration in addition to the three items in the multiple linear regression analysis. These points should be considered as specific recommendations for maternal and fetal lead exposure in this city.
本研究的目的是调查母亲及其脐带血中血铅浓度升高的患病率，并确定中国云南省昆明市产前铅暴露的危险因素。该研究在两个产科进行，招募了100名围产期妇女。母亲和脐带血的平均血铅浓度分别为67.3微克/升和53.1微克/升。在多元线性回归分析中，母亲的职业暴露、母亲食用自制脱水蔬菜的情况以及母亲在昆明市的居住时间与脐带血铅浓度升高显著相关。此外，采用逻辑回归分析评估可能对新生儿脑发育有不良影响的脐带血铅浓度与每个潜在危险因素之间的关联。除了多元线性回归分析中的三个因素外，母亲频繁使用内部有彩色图案的餐具也与较高的脐带血铅浓度显著相关。这些要点应被视为该城市母婴铅暴露的具体建议。
