[严重感染状态下的抗生素治疗]

[Antibiotic therapy in serious infectious states].

作者信息

Carlet J, Tabah A

机构信息

Service de réanimation polyvalente, fondation hôpital Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.

出版信息

Med Mal Infect. 2006 Jun;36(6):299-303. doi: 10.1016/j.medmal.2006.02.002. Epub 2006 May 15.

DOI:10.1016/j.medmal.2006.02.002

PMID:16698210

Abstract

Severe sepsis, which is related to a high mortality rate, requires a very specific antibiotic strategy, which must be adapted to each case. The appropriateness of empiric therapy is based on the delay before administration of the molecule, the bacterial resistance profile, and the kinetic and/or dynamic properties of the available antibiotics.

摘要

严重脓毒症与高死亡率相关，需要一种非常特定的抗生素治疗策略，且该策略必须根据具体病例进行调整。经验性治疗的合理性基于分子给药前的延迟时间、细菌耐药谱以及现有抗生素的动力学和/或动态特性。