[微透析与脑损伤：动物研究的重要性]
[Microdialysis and brain injury: importance of animal study].
作者信息
Geeraerts T, Friggeri A, Vigué B
机构信息
Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, France.
出版信息
Ann Fr Anesth Reanim. 2006 Jul;25(7):735-40. doi: 10.1016/j.annfar.2006.03.016. Epub 2006 May 15.
Brain microdialysis allows the exploration of brain extracellular medium. This review discusses the main contribution of brain microdialysis for the knowledge of the pathophysiology of brain ischemia and trauma. We describe fundamental principle of microdialysis, limits, and validated metabolic parameters as the lactate/pyruvate ratio or glycerol. The interest to use microdialysis for testing metabolic hypothesis and potential scientific research ways will also be discussed.
脑微透析技术能够对脑细胞外液进行检测。本文综述了脑微透析技术在脑缺血和创伤病理生理学研究中的主要贡献。我们阐述了微透析的基本原理、局限性以及诸如乳酸/丙酮酸比值或甘油等已得到验证的代谢参数。同时，还将讨论使用微透析技术验证代谢假说的意义以及潜在的科研方法。
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