氮杂脱氧腺苷：合成、酶学及抗HIV活性。
Azadideoxyadenosine: synthesis, enzymology, and anti-HIV activity.
作者信息
Nishonov Abdumalik A, Ma Xiaohui, Nair Vasu
机构信息
The Center for Drug Discovery and Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602, USA.
出版信息
Bioorg Med Chem Lett. 2006 Aug 1;16(15):4099-101. doi: 10.1016/j.bmcl.2006.04.085. Epub 2006 May 12.
PMID:16698265
Abstract
Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian adenosine deaminase and it is a substrate for adenosine kinase. It exhibits in vitro anti-HIV activity.
摘要
描述了一种氮杂核苷的合成，它是双脱氧腺苷的一种新类似物。该化合物仅被哺乳动物腺苷脱氨酶缓慢脱氨，并且是腺苷激酶的底物。它具有体外抗HIV活性。
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