狼疮患者系列出血中常见独特型PR4-Id的评估。
Assessment of common idiotype PR4-Id in serial bleeds from lupus patients.
作者信息
Pilcher C, Williams W, Isenberg D A
机构信息
Department of Rheumatology Research, University College & Middlesex Hospital Medical School, London.
出版信息
Autoimmunity. 1991;9(1):7-12. doi: 10.3109/08916939108997118.
Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression was not simply related to total immunoglobulin levels and the controlling mechanisms of idiotype expression on different isotypes remain a matter of conjecture.
在14名狼疮患者的系列采血样本中，已发现一种常见的DNA抗体独特型PR4-Id的水平有显著波动，特别是在IgM和IgA抗体上，在IgG上的波动较小。几乎没有发现PR4-Id水平反映疾病活动的确切例子。然而，独特型表达并非简单地与总免疫球蛋白水平相关，不同同种型上独特型表达的控制机制仍是一个推测的问题。
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