Rankin J A, Huang S S, Sostman H D, Gee J B, Reynolds H Y
Research Service, West Haven Veterans Hospital, New Haven, CT.
Sarcoidosis. 1991 Mar;8(1):19-28.
Analysis of epithelial lining fluid from the lungs of patients with sarcoidosis frequently suggests the presence of an alveolitis. Several markers of this inflammatory response were quantitated in bronchoalveolar lavage fluid and serum from 45 non-smoking patients with sarcoidosis. All markers were elevated significantly compared to those from 19 normal controls. The degree of statistical correlation among all data was assessed. Pulmonary function tests, 67Gallium lung scans, and a clinical index of disease activity also were quantitated. When patients were grouped by the number of abnormal BAL lavage and serum markers, those patients with elevated values of five or more of these markers had significantly worse clinical disease and lower carbon monoxide diffusing capacities. These results indicate that pulmonary sarcoidosis is an immunologically heterogeneous disease and that measurement of several markers of disease activity may be required to accurately estimate the activity of the lung disease.
结节病患者肺上皮衬液的分析结果常常提示存在肺泡炎。对45例不吸烟的结节病患者的支气管肺泡灌洗液和血清中的几种炎症反应标志物进行了定量分析。与19名正常对照者相比，所有标志物均显著升高。评估了所有数据之间的统计相关性程度。还对肺功能测试、镓-67肺扫描以及疾病活动临床指标进行了定量分析。当根据支气管肺泡灌洗和血清标志物异常的数量对患者进行分组时，这些标志物中有五项或更多项升高的患者，其临床疾病明显更严重，一氧化碳弥散能力更低。这些结果表明，肺结节病是一种免疫异质性疾病，可能需要测量几种疾病活动标志物才能准确评估肺部疾病的活动情况。
