Jurach Márcia Teresinha, Meurer Luise, Moreira Luis Fernando
Department of Surgery, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Arq Gastroenterol. 2006 Jan-Mar;43(1):14-9. doi: 10.1590/s0004-28032006000100006. Epub 2006 May 8.
p53 is a tumor suppressor gene that has been implicated in the pathogenesis of a wide range of tumors, including colorectal cancer.
To evaluate the prognostic significance of p53 protein expression, and to correlate with clinical and pathologic variables as well as survival.
Immunohistochemical staining for p53 protein was performed in a series of 83 patients with rectal cancer with a follow-up of at least 5 years.
Expression of nuclear protein was positive in 36 (43.4%) of the tumors. We found association between positive p53 and death, local recurrence, distant metastasis and overall recurrence and we also found association between p53 and death, local recurrence, metastasis and overall recurrence when analysis was adjusted to Astler-Coller stage and grade of differentiation.
p53 immunoexpression has shown to be an independent prognostic factor in these series.
p53是一种肿瘤抑制基因，与包括结直肠癌在内的多种肿瘤的发病机制有关。
评估p53蛋白表达的预后意义，并与临床和病理变量以及生存率相关联。
对一系列83例直肠癌患者进行p53蛋白免疫组织化学染色，随访至少5年。
36例（43.4%）肿瘤的核蛋白表达呈阳性。我们发现p53阳性与死亡、局部复发、远处转移和总体复发之间存在关联，并且在根据阿斯特勒-科勒分期和分化程度进行分析调整后，我们还发现p53与死亡、局部复发、转移和总体复发之间存在关联。
在这些系列研究中，p53免疫表达已被证明是一个独立的预后因素。
