Valle Antonio Carlos F do, Moreira Luiz Carlos, Almeida-Paes Rodrigo, Moreira João S, Pizzini Cláudia V, Muniz Mauro de Medeiros, Zancopé-Oliveira Rosely M
Department of Infectious Diseases, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Rev Inst Med Trop Sao Paulo. 2006 Mar-Apr;48(2):113-6. doi: 10.1590/s0036-46652006000200012. Epub 2006 May 8.
We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.
