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[亚马孙州里奥内格罗的慢性恰加斯病性心脏病。经血清学、临床检查、胸部X光、心电图和超声心动图确诊的三例新本地病例报告]

[Chronic chagasic cardiopathy in the Rio Negro, Amazon State. Report of three new autochthonous cases confirmed by serology, clinical examination, chest X-rays, electro and echocardiography].

作者信息

Xavier Sérgio Salles, Sousa Andréa Silvestre, Viñas Pedro Albajar, Junqueira Angela C V, Bóia Márcio Neves, Coura José Rodrigues

机构信息

Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ.

出版信息

Rev Soc Bras Med Trop. 2006 Mar-Apr;39(2):211-6. doi: 10.1590/s0037-86822006000200015. Epub 2006 May 5.

Abstract

We report three new autochthonous cases of chronic chagasic cardiomyopathy from Rio Negro, Amazon State, confirmed by serology (indirect immunofluorescence, ELISA and Western-blot for Trypanosoma cruzi infection), clinical examination, chest X-rays, electro- and echocardiography. The three patients were born and lived all their lives in the Rio Negro region working as piaçaba gatherers, where they were bitten several times by sylvatic triatomine bugs. The clinical feature was congestive heart failure and intraventricular conduction impairment in the three cases (right bundle branch block with left anterior hemiblock in two cases, left bundle branch block of 3rd degree in one), polymorphic ventricular extrasystoles in two cases and primary T wave inversion in another one. The echocardiographic evaluation showed a significant increasing of the left ventricular diameters with ejection fraction lesser than 36%, and myocardial segmental impairment pattern, including apical aneurysm and postero-inferior akinesia in the three patients. These are the first autochthonous cases of chronic Chagasic cardiomyopathy from the Brazilian Amazon state with echocardiographic pattern suggestive of Chagas' disease.

摘要

我们报告了3例来自亚马孙州里奥内格罗的慢性恰加斯病性心肌病本地新病例,这些病例经血清学检查(间接免疫荧光法、酶联免疫吸附测定以及针对克氏锥虫感染的蛋白质印迹法)、临床检查、胸部X光、心电图和超声心动图检查得以确诊。这3名患者均出生于里奥内格罗地区,并在当地以采集巴西棕榈纤维为生,他们都曾多次被野生锥蝽叮咬。3例患者的临床特征均为充血性心力衰竭和室内传导障碍(2例为右束支传导阻滞合并左前分支阻滞,1例为三度左束支传导阻滞),2例有多形性室性早搏,另1例有原发性T波倒置。超声心动图评估显示,3例患者左心室直径显著增加,射血分数低于36%,且存在心肌节段性损害模式,包括心尖部动脉瘤和后下壁运动减弱。这些是巴西亚马孙州首批慢性恰加斯病性心肌病本地病例,其超声心动图表现提示为恰加斯病。

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