Ikeda T, Daimaru N, Inutsuka S, Hayashi S, Shigematsu N, Nakashima T, Uemura T
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Sarcoidosis. 1991 Sep;8(2):120-4.
Sarcoidosis resolves spontaneously in many cases on a long-term basis. However, there are many cases whose resolution is delayed. We have experienced a frequent association of chronic tonsillitis (CTL), and dental caries in those patients of persistent course. We hypothesized that the presence of chronic or recurrent inflammatory foci in the upper airway may adversely affect the natural resolution of sarcoidosis. We analyzed the difference of regression of bilateral hilar lymphadenopathy on chest roentgenogram (CXR) in relation to changes in serum angiotensin converting enzyme (SACE) in sarcoidosis patients with and without CTL, and the effect of tonsillectomy (TLT) on the clinical course. In this study, we focused only on the tonsil for the sake of simplicity of analysis. Sarcoidosis resolved spontaneously in 10 of 28 (36%) patients with CTL and in 19 of 25 (76%) without CTL, and after TLT 9 cases became favorable in the course and the rate of unfavorable turned similar to those without CTL. The presence of CTL may be adversely related to the resolution of sarcoidosis.
结节病在许多情况下会长期自发缓解。然而，也有许多病例缓解延迟。我们在病程持续的患者中经常遇到慢性扁桃体炎（CTL）和龋齿的情况。我们推测上呼吸道慢性或复发性炎症病灶的存在可能会对结节病的自然缓解产生不利影响。我们分析了有或无CTL的结节病患者胸部X线片（CXR）上双侧肺门淋巴结肿大消退的差异与血清血管紧张素转换酶（SACE）变化的关系，以及扁桃体切除术（TLT）对临床病程的影响。在本研究中，为了分析简便，我们仅关注扁桃体。28例有CTL的患者中有10例（36%）结节病自发缓解，25例无CTL的患者中有19例（76%）自发缓解，TLT后9例病情好转，病情不利的发生率与无CTL的患者相似。CTL的存在可能与结节病的缓解呈负相关。
