大麻素在神经疾病中的作用
Implication of cannabinoids in neurological diseases.
作者信息
Alsasua del Valle Angela
机构信息
Dpto. Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Avda. Complutense s/n, Madrid, 28040, Spain.
出版信息
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):579-91. doi: 10.1007/s10571-006-9070-8. Epub 2006 May 12.
Abstract
- Preparations from Cannabis sativa (marijuana) have been used for many centuries both medicinally and recreationally. 2. Recent advances in the knowledge of its pharmacological and chemical properties in the organism, mainly due to Delta(9)-tetrahydrocannabinol, and the physiological roles played by the endocannabinoids have opened up new strategies in the treatment of neurological and psychiatric diseases. 3. Potential therapeutic uses of cannabinoid receptor agonists include the management of spasticity and tremor in multiple sclerosis/spinal cord injury, pain, inflammatory disorders, glaucoma, bronchial asthma, cancer, and vasodilation that accompanies advanced cirrhosis. CB(1) receptor antagonists have therapeutic potential in Parkinson's disease. 4. Dr. Julius Axelrod also contributed in studies on the neuroprotective actions of cannabinoids.
摘要
- 来自大麻（大麻）的制剂已经在医学和娱乐方面使用了许多世纪。2. 主要由于Δ⁹-四氢大麻酚，其在生物体中的药理和化学性质的知识最近取得了进展，并且内源性大麻素所起的生理作用为神经和精神疾病的治疗开辟了新策略。3. 大麻素受体激动剂的潜在治疗用途包括治疗多发性硬化症/脊髓损伤中的痉挛和震颤、疼痛、炎症性疾病、青光眼、支气管哮喘、癌症以及晚期肝硬化伴随的血管舒张。CB(₁)受体拮抗剂在帕金森病中有治疗潜力。4. 朱利叶斯·阿克塞尔罗德博士也对大麻素的神经保护作用的研究做出了贡献。
相似文献
1
Implication of cannabinoids in neurological diseases.大麻素在神经疾病中的作用
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):579-91. doi: 10.1007/s10571-006-9070-8. Epub 2006 May 12.
2
Therapeutic potential of cannabinoids in CNS disease.大麻素在中枢神经系统疾病中的治疗潜力。
CNS Drugs. 2003;17(3):179-202. doi: 10.2165/00023210-200317030-00004.
3
Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists.大麻衍生物和内源性大麻素激动剂的药理学与毒理学
Recent Pat CNS Drug Discov. 2010 Jan;5(1):46-52. doi: 10.2174/157488910789753521.
4
Cannabis and cannabinoids: pharmacology and rationale for clinical use.大麻与大麻素：药理学及临床应用原理
Forsch Komplementarmed. 1999 Oct;6 Suppl 3:12-5. doi: 10.1159/000057150.
5
The endocannabinoid system as a target for the treatment of motor dysfunction.内源性大麻素系统作为治疗运动功能障碍的靶点。
Br J Pharmacol. 2009 Apr;156(7):1029-40. doi: 10.1111/j.1476-5381.2008.00088.x. Epub 2009 Feb 13.
6
Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders.大麻素受体和内源性大麻素：在神经炎症和神经退行性疾病中的作用。
CNS Neurol Disord Drug Targets. 2010 Nov;9(5):564-73. doi: 10.2174/187152710793361568.
7
Endocannabinoid System: A Multi-Facet Therapeutic Target.内源性大麻素系统：一个多方面的治疗靶点。
Curr Clin Pharmacol. 2016;11(2):110-7. doi: 10.2174/1574884711666160418105339.
8
Recent data on cannabinoids and their pharmacological implications in neuropathic pain.近期关于大麻素及其在神经性疼痛中的药理学意义的数据。
J Med Life. 2008 Oct-Dec;1(4):365-75.
9
Cannabinoid receptors and their ligands.大麻素受体及其配体。
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):101-21. doi: 10.1054/plef.2001.0341.
10
Therapeutic potential of cannabinoid receptor ligands: current status.大麻素受体配体的治疗潜力：现状
Methods Find Exp Clin Pharmacol. 2006 Apr;28(3):177-83. doi: 10.1358/mf.2006.28.3.985231.
引用本文的文献
1
Poisonous Plants of the Indian Himalaya: An Overview.印度喜马拉雅地区的有毒植物：概述
Metabolites. 2022 Jun 13;12(6):540. doi: 10.3390/metabo12060540.
2
Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury.脊髓损伤后大麻素-2 选择性激动剂对炎症反应的调节。
J Neurotrauma. 2011 Dec;28(12):2417-27. doi: 10.1089/neu.2011.1853. Epub 2011 Oct 4.
3
Cannabinoids in health and disease.健康与疾病中的大麻素
Dialogues Clin Neurosci. 2007;9(4):413-30. doi: 10.31887/DCNS.2007.9.4/nkogan.
4
Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain: neuroprotection versus neurotoxicity.瞬时受体电位香草酸亚型1和大麻素1型受体在大脑中的作用：神经保护与神经毒性
Mol Neurobiol. 2007 Jun;35(3):245-54. doi: 10.1007/s12035-007-0030-1.
本文引用的文献
1
From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseases.从大麻到内源性大麻素与多发性硬化症：中枢神经系统自身免疫性疾病的一个范例
Curr Drug Targets CNS Neurol Disord. 2005 Dec;4(6):667-75. doi: 10.2174/156800705774933087.
2
Effects of exogenous and endogenous cannabinoids on GABAergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse.外源性和内源性大麻素对小鼠尾状核-壳核与苍白球之间GABA能神经传递的影响。
J Pharmacol Exp Ther. 2006 Feb;316(2):608-17. doi: 10.1124/jpet.105.092718. Epub 2005 Oct 7.
3
A role for cannabinoid CB1 receptors in mood and anxiety disorders.大麻素CB1受体在情绪和焦虑障碍中的作用。
Behav Pharmacol. 2005 Sep;16(5-6):315-31. doi: 10.1097/00008877-200509000-00005.
4
Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation.大麻素受体1基因敲除小鼠易受神经丝损伤和半胱天冬酶3激活的影响。
Neuroscience. 2005;134(1):261-8. doi: 10.1016/j.neuroscience.2005.02.045.
5
Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus.内源性大麻素对大鼠苍白球中[³H]-γ-氨基丁酸摄取的不同影响。
Exp Neurol. 2005 Jul;194(1):284-7. doi: 10.1016/j.expneurol.2005.02.012.
6
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.大麻素受体在调节啮齿动物纹状体神经递质释放中的作用：免疫化学与药理学联合分析
J Neurosci. 2005 Mar 16;25(11):2874-84. doi: 10.1523/JNEUROSCI.4232-04.2005.
7
The endocannabinoid system: physiology and pharmacology.内源性大麻素系统：生理学与药理学
Alcohol Alcohol. 2005 Jan-Feb;40(1):2-14. doi: 10.1093/alcalc/agh110. Epub 2004 Nov 18.
8
Towards cannabis and cannabinoid treatment of multiple sclerosis.迈向大麻和大麻素对多发性硬化症的治疗
Drugs Today (Barc). 2004 Aug;40(8):663-76. doi: 10.1358/dot.2004.40.8.850469.
9
Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study.大麻用于帕金森病的运动障碍：一项随机双盲交叉研究。
Neurology. 2004 Oct 12;63(7):1245-50. doi: 10.1212/01.wnl.0000140288.48796.8e.
10
On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures.内源性大麻素系统按需激活对神经元兴奋性和癫痫样发作的控制
Biochem Pharmacol. 2004 Nov 1;68(9):1691-8. doi: 10.1016/j.bcp.2004.07.007.
Zotero 插件