血浆结合蛋白在亲脂性维生素和类固醇细胞摄取中的作用。
The role of plasma-binding proteins in the cellular uptake of lipophilic vitamins and steroids.
作者信息
Andreassen T K
机构信息
Department of Medical Biochemistry, University of Aarhus, Denmark.
出版信息
Horm Metab Res. 2006 Apr;38(4):279-90. doi: 10.1055/s-2006-925348.
Steroid hormones and many other lipophilic compounds are believed to enter cells solely by free diffusion through the plasma membrane. However, recent work using a megalin-deficient mouse model has identified a new endocytic pathway responsible for the delivery of steroids to renal and gonadal tissues. This review describes these new pathways for uptake of 25-hydroxy-vitamin-D3 and the gonadal sex-steroids (17beta-estradiol and testosterone) bound to vitamin D-binding protein and sex hormone-binding globulin respectively. Furthermore examples of other lipophilic molecules that enter cells by receptor-mediated pathways will be presented and the receptors responsible for their uptake described.
类固醇激素和许多其他亲脂性化合物被认为仅通过自由扩散穿过质膜进入细胞。然而，最近使用巨蛋白缺陷小鼠模型的研究发现了一种新的内吞途径，该途径负责将类固醇输送到肾脏和性腺组织。这篇综述描述了这些摄取25-羟基维生素D3以及分别与维生素D结合蛋白和性激素结合球蛋白结合的性腺性类固醇（17β-雌二醇和睾酮）的新途径。此外，还将介绍其他通过受体介导途径进入细胞的亲脂性分子的例子，并描述负责其摄取的受体。
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