Larché Mark
Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, South Kensington, London SW7 2AZ, UK.
Immunol Allergy Clin North Am. 2006 May;26(2):321-32, viii. doi: 10.1016/j.iac.2006.02.005.
Synthetic peptides representing T-cell epitopes of allergens and autoantigens have been employed to induce antigen-specific tolerance in vivo in experimental models and the clinical setting. Delivery of peptides orally or by injection leads to reduced reactivity to antigen accompanied by the induction of T cells with a regulatory phenotype. Peptide therapy may provide a safe, effective, and economically viable approach for disease-modifying therapy in autoimmune and allergic diseases.
代表变应原和自身抗原T细胞表位的合成肽已被用于在实验模型和临床环境中体内诱导抗原特异性耐受。口服或注射肽可导致对抗原的反应性降低，并伴有具有调节表型的T细胞的诱导。肽疗法可能为自身免疫性疾病和变应性疾病的疾病修饰治疗提供一种安全、有效且经济可行的方法。
