Barlan Isil, Bahceciler Nerin N, Akdis Mübeccel, Akdis Cezmi A
Division of Pediatric Allergy and Immunology, Marmara University Hospital, 81190 Uskudar, Istanbul, Turkey.
Immunol Allergy Clin North Am. 2006 May;26(2):365-77, ix. doi: 10.1016/j.iac.2006.02.002.
Based on the hygiene hypothesis association between atopy and bacillus Calmette-Guerin (BCG), purified protein derivative skin test reaction, mycobacterial disease, and environmental mycobacteria are summarized. The role of mycobacterial species in the activation of the innate immune response through Toll-like receptors is mentioned. The implications and perspectives of BCG as a potential therapeutic adjuvant in atopic disease are discussed.
基于特应性与卡介苗（BCG）、纯化蛋白衍生物皮肤试验反应、分枝杆菌病和环境分枝杆菌之间的卫生假说关联进行了总结。文中提到了分枝杆菌属通过Toll样受体激活固有免疫反应的作用。讨论了卡介苗作为特应性疾病潜在治疗佐剂的意义和前景。
