Khater T T, Baker J F, Peterson B W
Department of Physiology, Northwestern University School of Medicine, Chicago, IL 60611.
J Vestib Res. 1990;1(1):23-9.
Adaptive modification of vestibuloocular reflex (VOR) direction was characterized in humans by recording vertical and horizontal VOR eye movements during horizontal rotations in darkness at frequencies of 0.05 to 1 Hz before and after exposure to a VOR direction adaptation procedure. This procedure paired yaw horizontal vestibular rotation at 0.25 Hz with synchronous pitch vertical optokinetic motion. Saccades were removed from eye position records and VOR gain and phase were recorded. With an onset time constant of 36 min, the VOR measured during horizontal rotation in complete darkness acquired a vertical component in phase with the optokinetic stimulus presented during adaptation. The amplitude of this newly acquired vertical VOR component was maximal during rotation at the frequency of adaptation; at other frequencies, the amplitude was lower, but still significant. Unlike VOR direction adaptation in cats, the phase of the adaptive VOR component in humans did not show significant leads or lags at test frequencies below or above the adaptation frequency. These data suggest that, like the cat, the human VOR can be directionally adapted, and the pathways involving the adaptive component of the VOR are frequency specific.
通过在黑暗环境中以0.05至1 Hz的频率进行水平旋转时记录垂直和水平前庭眼反射（VOR）眼动，来表征人类VOR方向的适应性改变。此过程发生在接受VOR方向适应程序之前和之后。该程序将0.25 Hz的偏航水平前庭旋转与同步俯仰垂直视动运动配对。从眼位记录中去除扫视，并记录VOR增益和相位。在36分钟的起始时间常数下，在完全黑暗中水平旋转期间测量的VOR获得了与适应期间呈现的视动刺激同相的垂直分量。这个新获得的垂直VOR分量的幅度在适应频率的旋转期间最大；在其他频率下，幅度较低，但仍然显著。与猫的VOR方向适应不同，人类适应性VOR分量的相位在低于或高于适应频率的测试频率下没有显示出明显的超前或滞后。这些数据表明，与猫一样，人类VOR可以进行方向适应，并且涉及VOR适应成分的通路具有频率特异性。
