Day M J
Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Langford BS40 5DU, United Kingdom.
Vet Microbiol. 2006 Oct 5;117(1):51-8. doi: 10.1016/j.vetmic.2006.04.017. Epub 2006 Apr 25.
The debate over adverse reactions associated with companion animal vaccination has considerably exercised the veterinary profession internationally over the past decade. A range of suspected adverse reactions to vaccines is reported including the onset of inflammatory, allergic, autoimmune or neoplastic diseases. Lack of efficacy, interference with diagnostic testing and other occasional suspected product-related issues are also reported. Available data suggest that the overall prevalence of true adverse reactions is exceedingly low and that vaccination does not significantly contribute to ill-health in companion animals. There is increasing public interest in vaccination issues with transfer of focus from publicity over human vaccine side effects to those perceived to occur in animals. We must not lose sight of the fact that vaccination is a safe procedure that has impacted significantly on infectious disease control. Reduced population uptake of vaccination leads to re-emergence of disease in both humans and animals. Nevertheless, there have recently been a series of practical recommendations produced to ensure reduced 'vaccine load' on our companion animals and vaccine manufacturers are moving towards developing non-adjuvanted products with an extended duration of immunity. These measures will further reduce the very small current risk of any adverse consequences to vaccination in our pet population.
在过去十年里，关于伴侣动物疫苗接种相关不良反应的争论在国际兽医界引发了广泛讨论。据报道，疫苗存在一系列疑似不良反应，包括炎症性、过敏性、自身免疫性或肿瘤性疾病的发作。也有关于疫苗缺乏效力、干扰诊断检测以及其他偶尔出现的疑似与产品相关问题的报道。现有数据表明，真正不良反应的总体发生率极低，疫苗接种对伴侣动物健康状况不佳的影响并不显著。公众对疫苗接种问题的关注度日益增加，关注点已从人类疫苗副作用的宣传转移到动物身上被认为会出现的副作用。我们绝不能忽视疫苗接种是一种安全程序这一事实，它对传染病控制产生了重大影响。疫苗接种的人群接受率降低会导致人类和动物疾病再次出现。尽管如此，最近已经提出了一系列切实可行的建议，以确保降低我们伴侣动物的“疫苗负担”，并且疫苗制造商正在朝着开发免疫持续时间更长的无佐剂产品迈进。这些措施将进一步降低目前宠物群体中疫苗接种产生任何不良后果的极小风险。
