非基因组印记引起的果蝇mRNA表达中的亲本来源效应。
Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting.
作者信息
Wittkopp Patricia J, Haerum Belinda K, Clark Andrew G
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
出版信息
Genetics. 2006 Jul;173(3):1817-21. doi: 10.1534/genetics.105.054684. Epub 2006 May 15.
Abstract
Parent-of-origin effects create differences in gene expression among genetically identical individuals. Using measurements of allele-specific expression, we demonstrate that previously reported parent-of-origin effects on standing mRNA levels in Drosophila melanogaster are not attributable to genomic imprinting. Offspring from reciprocal crosses exhibit differences in total expression without differences in allelic expression, indicating that other types of maternal and/or paternal effects alter expression.
摘要
亲本来源效应在基因相同的个体间造成基因表达差异。通过对等位基因特异性表达的测量，我们证明了先前报道的果蝇中亲本来源对稳态mRNA水平的效应并非由基因组印记导致。正反交后代在总表达上存在差异，但在等位基因表达上无差异，这表明其他类型的母本和/或父本效应会改变基因表达。
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