Levin P D
J Bone Joint Surg Br. 1975 May;57(2):234-7.
The effectiveness of different antibiotics mixed with Simplex P has been tested in vitro. A laboratory model was designed to simulate the constant immersion of bone cement in tissue fluid. Clindamycin, and to a lesser extent Cephalothin, were shown to be effective when used in this manner against Staphylococcus aureus and epidermidis. Effective inhibition of Gram-negative organisms could not be demonstrated with any of the antibiotics tested. The addition of up to 3 grams of antibiotic powder per unit of 40 grams of Simplex P did not appear to alter the expansive properties of the cement. Such release of antibiotics as did occur was thought to be related to the slow absorption of water by the slightly porous methyl methacrylate.
已在体外测试了不同抗生素与单纯型P骨水泥混合后的有效性。设计了一个实验室模型来模拟骨水泥在组织液中的持续浸泡。结果表明，以这种方式使用时，克林霉素以及在较小程度上的头孢噻吩对金黄色葡萄球菌和表皮葡萄球菌有效。所测试的任何一种抗生素都未能有效抑制革兰氏阴性菌。每40克单纯型P骨水泥添加多达3克抗生素粉末似乎并未改变骨水泥的膨胀特性。抗生素的这种释放被认为与微孔甲基丙烯酸甲酯对水的缓慢吸收有关。
