Bach Dominik R, Erdmann Gisela, Schmidtmann Marco, Mönnikes Hubert
Department of Medicine, Division Hepatology and Gastroenterology, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
Eur J Gastroenterol Hepatol. 2006 Jun;18(6):629-36. doi: 10.1097/00042737-200606000-00009.
Irritable bowel syndrome (IBS) has been proposed to be a stress-related disorder. Research on stress reactivity in IBS has yielded ambiguous results, regarding responses to physical and mental stress. This study aimed to investigate the responses to emotional stress in IBS patients.
Twelve IBS patients and 12 healthy individuals underwent public speaking anticipation as an emotional stressor and a control situation. Stress reactivity was quantified by subjective and psychophysiological measures.
Stress responses were elicited in healthy controls and IBS patients. Differential stress responses were observed in measurements of heart rate. There was no change in rectal sensitivity under stress, whereas patients exhibited lower discomfort thresholds than healthy controls in all conditions.
This study measured reactivity to an emotional stressor in IBS. It provides evidence that there is a specific alteration of stress responses in IBS patients, but no overall exaggerated stress response. IBS patients showed a broader and less specific response to emotional stress than healthy controls. Rectal sensitivity was unchanged under emotional stress both in IBS patients and healthy controls.
肠易激综合征（IBS）被认为是一种与压力相关的疾病。关于IBS患者对身心压力的反应，压力反应性的研究结果并不明确。本研究旨在调查IBS患者对情绪压力的反应。
12名IBS患者和12名健康个体接受公开演讲预期作为情绪应激源和对照情境。通过主观和心理生理测量对压力反应性进行量化。
健康对照组和IBS患者均出现应激反应。在心率测量中观察到不同的应激反应。应激状态下直肠敏感性无变化，而在所有条件下患者的不适阈值均低于健康对照组。
本研究测量了IBS患者对情绪应激源的反应性。提供了证据表明IBS患者存在应激反应的特定改变，但不存在整体过度应激反应。与健康对照组相比，IBS患者对情绪压力的反应更广泛且特异性更低。在情绪应激状态下，IBS患者和健康对照组的直肠敏感性均未改变。
