Dutz Jan P
Departments of Dermatology and Medicine and Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
J Invest Dermatol. 2006 Jun;126(6):1209-12. doi: 10.1038/sj.jid.5700238.
Dendritic cells are the coordinators of the adaptive immune response. Chronic activation of skin dendritic cells by keratinocyte expression of CD40 ligand (CD40L; CD154) leads to autoimmunity. In this issue, systemic administration of tacrolimus is shown by Loser et al. to effectively treat autoimmunity in a murine model involving transgenic keratinocyte expression of CD40L.
树突状细胞是适应性免疫反应的协调者。角质形成细胞表达的CD40配体（CD40L；CD154）对皮肤树突状细胞的慢性激活会导致自身免疫。在本期杂志中，Loser等人表明，在一个涉及转基因角质形成细胞表达CD40L的小鼠模型中，全身性给予他克莫司可有效治疗自身免疫。
