MPZL1/PZR，汉族人群中一个新的精神分裂症易感候选基因。

MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese.

作者信息

He G, Liu X, Qin W, Chen Q, Wang X, Yang Y, Zhou J, Xu Y, Gu N, Feng G, Sang H, Wang P, He L

机构信息

Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China.

出版信息

Mol Psychiatry. 2006 Aug;11(8):748-51. doi: 10.1038/sj.mp.4001841. Epub 2006 May 9.

DOI:10.1038/sj.mp.4001841

PMID:16702974

Abstract

The MPZL1/PZR gene has been mapped to 1q23.3, located in close proximity to a recognized schizophrenia susceptibility locus. Recently, the MPZL1/PZR gene has been found to be significantly upregulated in schizophrenia brain tissue and to play an important role in cell signaling, thus indicating that MPZL1/PZR could be a potential schizophrenia marker. To test this hypothesis, we selected three single nucleotide polymorphisms (SNPs) for genotyping in 523 Han Chinese trios. We found that two individual SNPs were significant at the Bonferroni's corrected significance level P<0.017: rs3767444 (chi2=6.299, P=0.0121) and rs2051656 (chi2=9.856, P=0.0017). Haplotype transmission/disequilibrium tests revealed a significant association with the disease (global P-value=1.064 x 10(-6)), but no specific transmission distortions. Thus, we propose that the MPZL1/PZR gene may be important in the predisposition to schizophrenia among Han Chinese.

摘要

MPZL1/PZR基因已被定位到1q23.3，该位置紧邻一个已确认的精神分裂症易感基因座。最近，人们发现MPZL1/PZR基因在精神分裂症脑组织中显著上调，并在细胞信号传导中发挥重要作用，因此表明MPZL1/PZR可能是一种潜在的精神分裂症标志物。为了验证这一假设，我们选择了三个单核苷酸多态性（SNP）对523个汉族三口之家进行基因分型。我们发现，在经Bonferroni校正的显著性水平P<0.017时，两个个体SNP具有显著性：rs3767444（卡方=6.299，P=0.0121）和rs2051656（卡方=9.856，P=0.0017）。单倍型传递/不平衡检验显示与该疾病存在显著关联（全局P值=1.064×10^(-6)），但没有特定的传递扭曲。因此，我们提出MPZL1/PZR基因可能在汉族人群精神分裂症的易感性中起重要作用。