Kuru Bahar, Yilmaz Selçuk, Argin Kiliçaslan, Noyan Ulkü
Dental Faculty, Department of Periodontology, Marmara University, Istanbul, Turkey.
Clin Oral Investig. 2006 Sep;10(3):227-34. doi: 10.1007/s00784-006-0052-5. Epub 2006 May 16.
This controlled clinical study investigated the clinical and radiographic outcome of wide intrabony periodontal defects treated by enamel matrix derivatives alone or in combination with a bioactive glass over a period of 8 months. Twenty-three chronic periodontitis patients, who received initial therapy and had radiographical interproximal defects with an associated probing depth of 6 mm or more and an intrabony component of at least 4 mm, were included. Each of the patients, contributing at least one intrabony defect, was treated with either enamel matrix derivative alone (group 1, n=10) or the combination (group 2, n=13). In both groups, all clinical and radiographical parameters were improved. Groups 1 and 2 presented a mean pocket reduction of 5.03+/-0.89 and 5.73+/-0.80 mm, recession of 0.97+/-0.24 and 0.56+/-0.18 mm, relative attachment gain of 4.06+/-1.06 and 5.17+/-0.85 mm, and radiographic bone gain of 2.15+/-0.42 and 2.76+/-0.69 mm, respectively. An intergroup comparison revealed significant differences for all of the parameters, yielding a more favorable outcome towards the combined approach. Within the limits of the study, both treatments resulted in marked clinical and radiographical improvements, but combined treatment seemed to enhance the results in the treatment of wide intrabony defects.
这项对照临床研究调查了单独使用釉基质衍生物或与生物活性玻璃联合使用治疗宽骨内牙周缺损8个月的临床和影像学结果。纳入了23名慢性牙周炎患者，他们接受了初始治疗，有影像学显示的邻面缺损，相关探诊深度为6mm或以上，骨内成分至少为4mm。每位至少有一个骨内缺损的患者，分别接受单独的釉基质衍生物治疗（第1组，n = 10）或联合治疗（第2组，n = 13）。两组的所有临床和影像学参数均有改善。第1组和第2组的平均袋深减少分别为5.03±0.89和5.73±0.80mm，牙龈退缩分别为0.97±0.24和0.56±0.18mm，相对附着获得分别为4.06±1.06和5.17±0.85mm，影像学骨增量分别为2.15±0.42和2.76±0.69mm。组间比较显示所有参数均有显著差异，联合治疗方法的结果更有利。在本研究范围内，两种治疗均导致明显的临床和影像学改善，但联合治疗似乎能增强宽骨内缺损的治疗效果。
