Lee S, Tsirbas A, McCann J D, Goldberg R A
David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Eur J Ophthalmol. 2006 Mar-Apr;16(2):199-203. doi: 10.1177/112067210601600201.
To report the clinical and pathophysiologic features of two patients with Mikulicz's disease and to further characterize recommendations for diagnosis and management with a review of the literature.
Retrospective nonrandomized consecutive case series, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA.
Mikulicz's disease is characterized by symmetric lacrimal, parotid, and submandibular gland enlargement with associated lymphocytic infiltrations. The authors noted two cases of Mikulicz's disease. The diagnosis of Mikulicz's disease was based on the following criteria: 1) symmetric and persistent swelling of the lacrimal glands and either or both of the major salivary glands (parotid and submandibular); and 2) the exclusion of other diseases that may mimic this presentation, such as sarcoidosis, viral infection, or lymphoproliferative disorders.
Mikulicz's disease is a condition in which there is bilateral lacrimal and salivary gland swelling that is not associated with other systemic conditions. The condition is self-limiting and most often, the diagnosis is a clinical one. Previously, Mikulicz's disease was often considered as a subtype of Sjögren's syndrome (SS). Clinical and immunologic differences between Mikulicz's disease and SS may warrant further consideration of Mikulicz's disease as a specific autoimmune phenomenon separate from SS, and Mikulicz's disease may be amenable to different treatment modalities than those employed in patients with SS.
报告两例米库利奇病患者的临床和病理生理特征，并通过文献回顾进一步阐述诊断和管理建议。
回顾性非随机连续病例系列，加利福尼亚大学洛杉矶分校大卫·格芬医学院朱尔斯·斯坦眼科研究所。
米库利奇病的特征是泪腺、腮腺和颌下腺对称性肿大并伴有淋巴细胞浸润。作者记录了两例米库利奇病病例。米库利奇病的诊断基于以下标准：1）泪腺以及主要唾液腺（腮腺和颌下腺）中的一个或两个出现对称性持续性肿胀；及2）排除其他可能类似此表现的疾病，如结节病、病毒感染或淋巴增殖性疾病。
米库利奇病是一种双侧泪腺和唾液腺肿胀且与其他全身性疾病无关的病症。该病症具有自限性，多数情况下，诊断依靠临床判断。以前，米库利奇病常被视为干燥综合征（SS）的一种亚型。米库利奇病与SS在临床和免疫学上的差异可能值得进一步考虑将米库利奇病视为一种独立于SS的特定自身免疫现象，并且米库利奇病可能适用与SS患者不同的治疗方式。
