VAV原癌基因产物的过表达与13q缺失的B细胞慢性淋巴细胞白血病相关。
Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q.
作者信息
Prieto-Sánchez Rosario M, Hernández José A, García Juan L, Gutiérrez Norma C, San Miguel Jesús, Bustelo Xosé R, Hernández Jesús M
机构信息
Centro de Investigación del Cáncer, Hospital Clínico Universitario de Salamanca, Salamanca, Spain.
出版信息
Br J Haematol. 2006 Jun;133(6):642-5. doi: 10.1111/j.1365-2141.2006.06094.x.
Abstract
The expression of the VAV proto-oncogene in 57 patients with chronic myeloproliferative disease (CMD), B-cell acute lymphoblastic leukaemia (B-ALL) and B-cell non-Hodgkin Lymphoma (B-NHL), and 61 with B-cell chronic lymphocytic leukaemia (B-CLL) was analysed. VAV overexpression was observed in 19.5% of cases and 81% of VAV-positive tumours also displayed VAV phosphorylation. Overexpression was not observed in B-ALL or CMD, but 13% of B-NHL and 34.4% of B-CLL patients (P = 0.002) overexpressed VAV. The overexpression and phosphorylation of VAV was detected more frequently in 13q- chronic lymphocytic leukaemias (71.4%) versus other B-CLLs (23.4%, P = 0.001). Overexpression of VAV protein is a frequent event in patients with B-CLL displaying loss of 13q sequences.
摘要
分析了57例慢性骨髓增殖性疾病（CMD）、B细胞急性淋巴细胞白血病（B-ALL）和B细胞非霍奇金淋巴瘤（B-NHL）患者以及61例B细胞慢性淋巴细胞白血病（B-CLL）患者中VAV原癌基因的表达情况。在19.5%的病例中观察到VAV过表达，并且81%的VAV阳性肿瘤也显示出VAV磷酸化。在B-ALL或CMD中未观察到过表达，但13%的B-NHL患者和34.4%的B-CLL患者（P = 0.002）VAV过表达。与其他B-CLL相比，13q-慢性淋巴细胞白血病中VAV的过表达和磷酸化检测更为频繁（71.4% 对23.4%，P = 0.001）。VAV蛋白过表达在显示13q序列缺失的B-CLL患者中是常见事件。
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